AKT1 and major depressive disorder: Among these pathways, the literature review showed a significant association between the PI3K-Akt signaling pathway (hsa04151) and MAPK signaling pathway (hsa04010) in the depression pathophysiology, suggesting targeting of these pathways by A. laxiflora’s bioactive compounds as a possible mechanism of action (Su et al., 2017; Li et al., 2023).