A. laxiflora treated depression by targeting multiple vital targets such as SRC, STAT3, EGFR, PIK3R1, AKT1, MAPK1, AR, VEGFA, ESR1, and PTK1, and through biological processes such as signaling transduction, negative regulation of the apoptotic process, and positive regulation of transcription from RNA polymerase II promoter. Here, EGFR is linked to major depressive disorder.