Notably, recent studies had shown that glycyrrhizic acid might improve diabetes-induced sublingual gland damage by regulating oxidative stress, autophagy (including LC3B, Beclin-1, P62/SQTM1 targets), and angiogenesis, so as to restore the homeostasis of oral environment (Asseri et al., 2022). The gene discussed is SQSTM1; the disease is diabetes mellitus.