It is possible to colonize the host by attaching to components of the ECM to initiate infection (Foster and Höök, 1998), such as cell wall-attached fibronectin-binding proteins A and B that allow bacteria to bind tightly to the ECM protein fibronectin (FN) (Flock et al., 1987; JÖNsson et al., 1991). Here, FN1 is linked to infection.