RHOA and familial pancreatic carcinoma: ASIC1 and ASIC3 are mainly expressed on the membrane of pancreatic cancer cells and upregulated in pancreatic cancer tissues, and ASIC1 and ASIC3 promote acid-induced EMT of pancreatic cancer by activating the Ca2+/RhoA pathway, leading to the metastasis of pancreatic cancer (Zhu et al., 2017).