Two signaling pathways may be involved in this regulation: i) The OGR1/Gq/PLC/Ca2+/MEK/ERK pathway: Huang et al. demonstrated that OGR1 can activate gene transcriptional pathways in response to Ca2+ release from intracellular Ca2+ stores, thereby activating the MEK/ERK pathway and participating in tumor formation (Huang et al., 2008). Here, GPR68 is linked to neoplasm.