SYNGAP1 and epilepsy: The rationale for this phenomenon is not clear, since occipital epileptiform discharges in SYNGAP1 patients are mainly observed at 2-3 years, after the onset of epilepsy (Mignot et al., 2016; Jimenez-Gomez 2019; Lo Barco et al., 2021), by which time the critical period of neuronal myelination has already ended (Gilmore et al., 2018).