As shown in Fig. 4, associations within the core Alzheimer’s disease pathology cluster remained relatively stable across the disease trajectory (i.e. in preclinical and cognitive impairment stages), while the neurodegeneration, AT8-associated tau phosphorylation and neuronal dysfunction and inflammation clusters demonstrated shifts, especially later in the disease course. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.