MAPT and early-onset autosomal dominant Alzheimer disease: Within the core Alzheimer’s disease pathology cluster, amyloid PET associated with CSF Aβ42/40lumi and several CSF phosphorylated tau sites including pS208/S208, pT231/T231, pT153/T153, pT111/T111 and pT217/T217 (see Figs 1–3).