MAPT and amyloidosis: Tau PET was strongly associated with cognitive status in amyloid PET-positive individuals and its prominence in this model is highly consistent with previous literature.58,59 Although typically thought to reflect early disease changes, our models suggest CSF t-tau/Aβ40lumi, p-tau/Aβ40lumi and pT217/T217 reflect a degree of increasing disease severity at least through the early stages of cognitive impairment and reflect and intermediate process between early amyloidosis and the formation of NFTs.