Among them, six included studies (39, 41–45) provided the clinical data from osteoporosis patients (Table 1), 17 studies (12, 37, 38, 40, 46–58) reported the molecular mechanisms underlying the role of TLR4 in osteoporosis (Table 2), and seven studies (59–65) provided the data of specific treatments-targeted TLR4 for osteoporosis (Table 3). Here, TLR4 is linked to osteoporosis.