Here’s a further analysis of the correlation between the increased activity in these pathways and the enhanced drug sensitivity: (1).Increased Activity in Cell Signaling Pathways: DRGcluster A shows higher activity in several cell signaling pathways relevant to cancer, such as EGFR, VEGF, JAK/STAT, P53, MAPK, and TGF-beta. This evidence concerns the gene TP53 and cancer.