Future experiments to study the macrophage specific role of CBL-B in atherosclerosis will include the generation of a macrophage specific, CBL-B deficient mouse model mouse (e.g. Apoe-/-LysMcreCbl-bfl/fl) or macrophage depletion studies in which we reconstitute ApoE-/- mouse with CBL-B deficient versus wild type macrophages. The gene discussed is CBLB; the disease is atherosclerosis.