In the current study, we analyzed the association between the TS 3'UTR genotype and promoter methylation status of 8 tumor-specific genes, hTERT, hMLH1, MSH2, MMP2, CDH1, p14, p16, and p21 in 22 unselected series of sporadic CRC patients. This evidence concerns the gene MLH1 and colorectal carcinoma.