In the present study, we evaluated the association between the 3'UTR genotype of TS and methylation status of 8 tumor-related genes, including hTERT, hMLH1, MSH2, MMP2, CDH1, p14, p16, and p21 in CRC patients to define the possible molecular mechanisms that associate the TS 3′UTR genotype and CRC susceptibility. The gene discussed is MSH2; the disease is neoplasm.