Possible reasons for this association include biological differences in the immune response, increased expression of angiotensin-converting enzyme-2 and transmembrane protease serine 2 receptors in women compared to men, production of pro-inflammatory interleukin-6, a greater tendency for autoimmunity in females than in males, and a potential impact of sex hormones (38, 39). Here, IL6 is linked to Autoimmunity.