The reaction of astrocytes to remote ischemia in the hippocampus are consistent: the GFAP levels and the numbers of GFAP-positive (GFAP+) cells increase shortly after the stroke (Haupt et al., 2007; Nowicka et al., 2008; Uchida et al., 2010) and remain elevated for several months (Ouyang et al., 2020; Brait et al., 2021). The gene discussed is GFAP; the disease is Stroke.