S100A8 and aneurysm: Recently, a clinical study involving 63 patients reported that the median concentration of S100A8/A9 in the venous blood of aneurysm patients was 1257 ng/ml, significantly exceeding the median S100A8/A9 concentration of 390 ng/ml in healthy individuals (p ≤ 0.001); the median concentration of S100A8/A9 in ruptured aneurysms was 8530 ng/ml, which was significantly surpassed in unruptured aneurysms (p = 0.04).117