Specifically, considering the intimate association between CVD and inflammation, with S100A9 playing a prominent role as an inflammatory factor, we aim to summarize the intricate involvement of S100A9 in inflammation‐associated CVD, including atherosclerosis, myocardial infarction (MI), pulmonary arterial hypertension (PAH), aortic aneurysm, peripheral arterial disease (PAD), and so on (Table 1). This evidence concerns the gene S100A9 and aortic aneurysm.