The decrease in serum TNF‐α and IL‐6 produced by valsartan at 1 and 4 weeks of treatment may be associated with the effects previously described in patients with essential hypertension, who showed a reduction in blood pressure and serum TNF‐a and IL‐6 cytokines after treatment with valsartan (80 mg/day) for 3 months.37 The gene discussed is IL6; the disease is essential hypertension.