Hence, in addition to affecting CSCs, we hypothesized that LINC00909 may promote PC metastasis via MAPK/JNK signaling pathway, which is also due to reduction of SMAD4. In the future, it will be of interest to investigate whether MAPK/JNK activation is required for maintaining PC stemness. The gene discussed is ZNF407-AS1; the disease is pachyonychia congenita.