In the present research, we found that the effect of LINC00909 on pluripotency factors was dependent on the inhibition of SMAD4. SMAD4, also termed DPC4 (deleted in pancreatic cancer) [18], acts as a vital role in embryonic stem cell pluripotency, tumor progression, etc. Of note, loss of SMAD4 is a major contributor to PDAC tumorigenesis. Here, SMAD4 is linked to familial pancreatic carcinoma.