NOTCH3 and neoplasm: Proteins associated with tumor progression or a bad prognosis such as WNT5A, MMP13, MMP3, telomerase, and NOTCH3 were upregulated while proteins associated with immune cell infiltration or pathway inhibitors/tumor suppressors such as FRZB, CD177, PPARG, and HRASLS2 were downregulated (Fig. 4B).