While the overlaps with human CRCs are striking and range from similar mutational signatures, cancer-associated mutations, transcriptional profiles, clinical appearance, and even correlation of particular parameters such as ARID1A mutations with CIMP positivity, we also observe a disparity with respect to an overrepresentation of KRAS mutations and an underrepresentation of BRAF mutations (particularly V600E) in respect to human CRCs of this phenotype. The gene discussed is KRAS; the disease is cancer.