The SMR analyses uncovered the genetic connections of anal carcinoma risk with ABCC8 (OR = 1.762; 95% CI: 1.034–3.022; P-value = 0.037) and DPP4 (OR = 0.100; 95% CI: 0.011–0.893; P-value = 0.039) (Supplementary Table S10). The gene discussed is ABCC8; the disease is anal carcinoma.