Associations of ABCC8/KCNJ11, DPP4, GLP1R, GPD2, PPARG, PRKAB1, and SLC5A2 with anal carcinoma, cardia cancer, gastric cancer, HCC, ICC, pancreatic cancer, and rectum cancer were revealed in two-sample MR analyses. The gene discussed is PRKAB1; the disease is cardia cancer.