MAPT and Huntington disease: Based on the observations that a partial loss of Drp1 function reduces protein aggregation in experimental models of PD [12, 13], AD [14, 15], and HD [16], as well as a recent study reporting that abnormal levels of autophagy related genes in the transgenic Tau-P301L mice are significantly normalized when crossed with Drp1+/− mice, the role of Drp1 in autophagy is not confined to Mn-induced neurotoxicity.