Based on our center's cohort of ATAAD patients October 1, 2020 to April 1, 2023, we found that 1 an easy formula could be used to define postoperative hyper-inflammation (PCT > 2.18 ng/ml & CRP > 49.76 mg/L & IL-6 > 301.88 pg/ml & SII < 2509.96 × 109/L); 2 The morbidity of hyper-inflammation was about 12.83% in patients after ATAAD surgery, which was significantly associated with high mortality and morbidity; 3 the pre-operative bowel ischemia, pre-operative limb ischemia, CPB > 180 min and DHCA > 40 min were independent risk factors for postoperative hyper-inflammation. The gene discussed is CRP; the disease is limb ischemia.