In the current study, we found that the severe COVID-19 group had significantly higher values of blood and urine cadmium, significantly higher values of urine nickel, significantly higher neutrophil/lymphocyte ratio, significantly higher values of inflammatory markers including ferritin, LDH, CRP and IL-6, and higher rate of oxygen support than the non-severe COVID-19 group. The gene discussed is IL6; the disease is COVID-19.