CUGBP Elav-like family (CELF) and muscleblind-like (MBNL) proteins are some examples of RBPs functioning as splicing regulators; they play vital roles in myotonic dystrophy by promoting opposite effects on the splice site or exon usage, affecting mRNA localization and stability in the cytoplasm [17]. The gene discussed is MBNL1; the disease is myotonic dystrophy.