The present study demonstrated that ART1 knockdown significantly inhibited IL-6-induced p-STAT3 and its target proteins, c-Myc, cyclin D1 and Bcl-xL (Fig. 2D, amp and E, 3 A-D, 7D & E), the proliferation of CRC cells (Fig. 2A-C, F-I) and the growth of transplanted tumours in a mouse model (Fig. 7B & C). This evidence concerns the gene STAT3 and colorectal carcinoma.