The other study displayed that Lactobacillus paracasei N1115 dietary supplementation diminished serum total triglyceride and cholesterol, decrease the fasting blood glucose and insulin and can effectively prevent and treat NAFLD in an experimental model that was partly associated with repression of inflammatory factors such as lipopolysaccharides, TLR4 and NF-kB [54]. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.