IL1B and obesity due to melanocortin 4 receptor deficiency: Their results indicated that probiotics could significantly prevent or lower the rate of obesity, protect animals against the development of obesity, improve obesity related insulin resistance [40], ameliorate insulin resistance [45], prevent NAFLD progression [10] and hepatic steatosis [41], and alleviate the progression of diabetes [28] that these effects were mediated partly via decreasing IL-1β.