Probiotics intake improved glucose control and tolerance [43, 44, 46, 48–50], decrease insulin resistance [44–48], increase insulin sensitivity [46, 49], diminish HbA1c [40, 49, 50], reduce cardio- metabolic risks such as declining TG and cholesterol, rising HDL concentration [46, 48] and decreasing diabetic associated damages in the liver [44, 50] and pancreas [44] that generally alleviated the progression of diabetes. This evidence concerns the gene INS and diabetes mellitus.