Apart from uncovering new potential repositioning opportunities for hypertension, and illuminating BP-related effects of drugs used in other conditions than hypertension, our analyses provide specific cues into targets already tested in clinical trials (i.e. glutamyl aminopeptidase encoded by ENPEP) or those emerging as novel therapeutic strategies for hypertension [(e.g. suppression of AGT mRNA expression using antisense oligonucleotides118]. Here, AGT is linked to hypertensive disorder.