Recently, microRNAs have become famous for cancer treatment however, some previous studies identified, upregulated miR-26a-5p to be a tumor suppressor oncomir in CRC and sponge or a mediating oncomir that regulated autophagy, cell migration, cell proliferation, and invasion via the PI3K-AKT pathway in CRC18,45–51. The gene discussed is AKT1; the disease is colorectal carcinoma.