Considering that IFNα is correlated with HIV load, we assume that during the initial phase of infection, elevated IFNα, infected CD4+T cells, and HIV form a pathogenic vicious cycle from HIV infection to increased IFNα to increased viral load: HIV → IFNα → infected CD4+T cells → more HIV → more IFNα and so on. The gene discussed is IFNA2; the disease is HIV infectious disease.