NNMT and colorectal cancer: Equally, NNMT upregulation had been induced in SW480 colorectal cancer cells lines which lack endogenous NNMT expression, whereas NNMT silencing has been performed in HT-29 cells with high constitutive enzyme expression, showing that NNMT enhances cell proliferation and colony formation, inhibits apoptotic pathway, promotes cell cycle, and increases ATP levels [28].