However, currently except that NEK2 is found able to regulate gastric cancer progression through AKT/HIF-1α, AKT/mTOR, ERK/MAPK and β-catenin/myc/KDM5B signaling, only Gong Kunmei et al. found that circPDSS1/miR-86-5p/NEK2 signal could promote the progression of gastric cancer [28]. This evidence concerns the gene HIF1A and gastric cancer.