In recent years, studies focus on the roles of protooncogenes of NEK2. It was reported that NEK2 activates YAP signals by interacting with striating-interacting phosphatase and kinase (STRIPAK) complex, promotes the expression of target genes CTGF, CYR61 and GLI2, thereby promoting the proliferation of cervical cancer cells [22]. The gene discussed is CCN2; the disease is cervical cancer.