In order to determine whether NEK2 regulates the ferroptosis sensitivity of gastric cancer cells through HMOX1, we inhibited the expression of HMOX1 on the basis of NEK2 knockdown in vitro, and the results showed that inhibiting HMOX1 on the basis of NEK2 knockdown, the cell viability increased compared with NEK2 knockdown alone (Fig. 3A, B), and the level of Fe2+ showed the same change (Fig. 3C). Here, HMOX1 is linked to gastric cancer.