WDR5 and gastric cancer: In recent years, studies have found that ferroptosis is involved in the progression of gastric cancer, tumor stemness and resistance to chemotherapy drugs, etc. For example, Guoquan Huang et al. found that BDNF-AS is highly expressed in gastric cancer tissues, suggesting a worse prognosis and inhibiting BDNF-AS can enhance the susceptibility of gastric cancer cells to Erastin and RSL3-induced ferroptosis through WDR5/FBXW7/VDAC3 [16].