CDK12 and cancer: By visualizing the TNM staging of 12 types of cancer from the TCGA database examining the CDK12 expression levels (Fig.4), we found that 10 types of cancer had significantly higher CDK12 expression at advanced stages compared to earlier stages; these cancers included BRCA, CHOL, COAD, ESCA, HNSC, LIHC, LUAD, LUSC, READ and STAD.