OGG1 and hepatocellular carcinoma: Besides, LEI110 not only induced the accumulation of DNA damage and the suppressed expression of multiple DDR genes, but it also sensitized HCC cells towards multiple DNA damage-inducing reagents, such as hydroperoxide, hydroxyurea, OGG1 inhibitor (TH5487), and Cisplatin (Fig. 2 and Supplementary Fig. 6).