Similar to the reported effects of MSCs in chemically-induced colitis, BM-MSC treatments in Winnie mice downregulated the expression of Il6, Ifng, Il1b, Il1a, Tnf, Cxcl2, Tbx21 and Itgam, which were upregulated in Winnie mice and IBD patients. The gene discussed is TNF; the disease is colitis.