CD4 and neoplasm: Syngeneic mouse tumor model using another mouse cancer cell line LL/2 engineered to overexpress mouse galectin 7 also showed a reduction in the percentage of CD4+ and CD4+ CD25 + regulatory T cells in the galectin 7 overexpression group, further supporting CD4+ T cell suppressive effect of galectin 7 (Supplemental Fig. 1a).