The most commonly mutated genes in ccRCC include the von Hippel–Lindau (VHL) gene and chromatin-remodeling genes such as breast cancer 1 (BRCA1) associated-protein 1 (BAP1), SET domain-containing 2 (SETD2), and polybromo 1 (PBRM1) [5]. The gene discussed is SETD2; the disease is nonpapillary renal cell carcinoma.