TFE3 and neoplasm: Additionally, in NONO-TFE3 translocation renal cell carcinoma (NONO-TFE3 tRCC), a subtype of RCC associated with Xp11.2 translocation/TFE3 gene fusions RCC (Xp11.2 tRCCs), YTHDF2 played a tumor-suppressive role by suppressing poly(ADP-ribose) polymerase 1 (PARP1) expression.