While HLA and TLR associations provide a proof of principle establishing Lyme disease as an infectious trait that is modified by genetic risk factors, the strongest and most compelling association was found at Secretoglobin family 1D member 2 locus (SCGB1D2, rs2232950, P = 8.10 × 10−86, Fig. 1) and the same lead variant associating in FinnGen (SCGB1D2, rs2232950, P = 6.12 × 10−31) and in Estonian Biobank (SCGB1D2, rs2232950, P = 1.02 × 10−56, Supplementary Fig. 4). The gene discussed is SCGB1D2; the disease is Lyme disease.