We hypothesized that knockdown of RBBP6 induced widespread 3’UTR shortening (3’US) of genes in cancer cells, which in turn resulted in releasing their miRNAs to repress their ceRNA partners in trans, such as MYC. To test this hypothesis, we used model-based analysis of the trans-effect of 3’UTR shortening (MAT3UTR) to predict the trans-effect of 3’US to their ceRNA partners20. This evidence concerns the gene RBBP6 and cancer.