Furthermore, RNA sequencing (RNA-seq) and H3K27ac (Histone 3 lysine 27 acetyl, a marker of active enhancer and promoter regions) chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) data from our group and other published datasets12,13 showed that RBBP6 was preferentially expressed in GSCs relative to normal neural stem cells (NSCs) and differentiated glioblastoma cells (DGCs) (Fig. 1e–g). The gene discussed is RBBP6; the disease is glioblastoma.