Interestingly, AML cells harbouring KMT2A rearrangements in vitro transformed mouse bone marrow (BM), Cas9 Flt3-ITD MLL-AF4 (IC50 = 0.96) and Cas9 Flt3-ITD MLL-AF9 (IC50 = 2.55), and human MV-4-11 (IC50 = 2.05) and MOLM-13 (IC50 = 2.58), which have a mutational spectrum equivalent to that of transformed mouse BM lines, were especially sensitive to PL. Here, FLT3 is linked to acute myeloid leukemia.