Among the subsets of AML subtypes characterised by the expression of the CD34 stem/progenitor marker, AML-LSCs exhibit a CD34+CD38- phenotype and can express other markers, including CD123, CD45RA, CD96, CLL-1, TIM-3, CD93 and CD99 [3, 4, 11, 12]. The gene discussed is CD34; the disease is acute myeloid leukemia.