By inferring the contribution of 896 expressed TFs to the activity of the MD-enriched CREs, we identified many TFs motifs that have been previously described to play a role in breast cancer progression and metastasis (Fig. 4b, Supplementary Data 3), including EBF1, HE1, HMGA1, XBP1 and SOX9. Here, NPC2 is linked to breast carcinoma.