TRIM16 and ocular melanoma: Keap1 acts as a negative regulator of Nrf2 by binding to it, hindering Nrf2 from entering the nucleus.[40] Keap1 degradation enables Nrf2 translocation to the nucleus, thereby enhancing downstream protein expression.[40, 41] The Trim family of E3 ligases regulates Keap1 homeostasis through ubiquitination, with Trim25 being identified to interact with and promote Keap1 ubiquitination.[42] In this study, morusin's effect on Trim family expression was explored, revealing an increase in Trim proteins, specifically Trim16 and Trim25, in OM‐induced VICs (Figure7A).