Keap1 acts as a negative regulator of Nrf2 by binding to it, hindering Nrf2 from entering the nucleus.[40] Keap1 degradation enables Nrf2 translocation to the nucleus, thereby enhancing downstream protein expression.[40, 41] The Trim family of E3 ligases regulates Keap1 homeostasis through ubiquitination, with Trim25 being identified to interact with and promote Keap1 ubiquitination.[42] In this study, morusin's effect on Trim family expression was explored, revealing an increase in Trim proteins, specifically Trim16 and Trim25, in OM‐induced VICs (Figure7A). This evidence concerns the gene KEAP1 and ocular melanoma.