Senescent cells can create an aging microenvironment by secreting cytokines, chemokines, and matrix metalloproteinases and can be identified by β‐gal staining.[13] The number of β‐gal‐positive VICs significantly increased upon OM stimulation, while CCND1 knockdown reduced the number of OM‐induced β‐gal‐positive VICs (Figure 4L,M). Here, CCND1 is linked to ocular melanoma.