NQO1, a ubiquitous flavoenzyme that catalyzes quinones, utilizes NADH, and generates NAD+, plays a crucial role in maintaining intercellular homeostasis and protecting DNA from oxidative stress.[61, 62] Heme oxygenase‐1 (HMXO‐1), a well‐known antioxidant, is found to alleviate ER stress.[63, 64] The data indicated downregulated expression of NQO1 and HMXO‐1 in calcific valvular tissue and OM‐induced VICs, indicating an antioxidant deficiency leading to valvular calcification. The gene discussed is NQO1; the disease is ocular melanoma.