TP53 and ocular melanoma: A tight association exists between the activation of the CCND1/P53/P21 signaling pathway and VIC calcification.[35] In the present investigation, immunoblot analysis demonstrated an increase in the expression of CCND1, P21, and P53 during the osteogenic differentiation of VICs, while treatment with morusin inhibited the CCND1/P53/P21 signals in OM‐induced VICs (Figure 3E–H).