Notably, Cdkn1a, which codes for the cell-cycle inhibitory protein p21, and Fbp1, which codes for fructose bisphosphatase-1 identified as a tumor suppressor in ccRCC (41), were specifically upregulated following Vhl inactivation in CDIC, but not PT cells (Supplementary Fig. S2C). This evidence concerns the gene PROS1 and nonpapillary renal cell carcinoma.