Based on these findings, the AKI predictive reasoning in cluster 4 can be interpreted as “patients with terminal cancer and cachexia who developed AKI due to worsening conditions or diuretic use, high CRP and LDH levels, and poor dietary intake.” In addition, when the dependence plots of CRP and LDH were color-coded by cluster, higher values of the features and SHAP were frequently observed in clusters 3 and 4 (Fig 3c). The gene discussed is CRP; the disease is acute kidney injury.