Substantiating our findings, our immunohistochemical staining revealed the presence of GFAPhighAQP4+CD63+ and GFAPlowAQP4+ CD63+ cells within the cortex of late-onset AD model APPNL-F/NL-F knock-in (APP NL-F) mice and in control sample [36] (Fig. 5G). Here, CD63 is linked to Alzheimer disease.