They found the processing of proBNP is dysregulated in patients with HF, and increased BMI is associated with decreased concentrations of proBNP not glycosylated at Thr71 (NG-Thr71), the authors concluded that impairment of proBNP processing owing to glycosylation of Thr71 is relevant to reduce plasma concentrations of BNP and NT-proBNP observed in obesity. Here, NPPB is linked to obesity due to melanocortin 4 receptor deficiency.