B4GALNT1 and cardiovascular disorder: Growing evidence supports the different roles of GalNAc-Ts in modulating cell signaling pathways and targeting proteins that are critical for maintaining cardiovascular homeostasis, for example: 1) Mutations in the GalNAc-Ts are linked to modifications of plasma lipid concentrations, which in turn increases the susceptibility to cardiovascular diseases (CVDs) [8, 9].