For example, nonreceptor tyrosine kinases (e.g., Src and Yes) can phosphorylate YAP and promote an interaction with the runt domain transcription factor 2 (Runx2), which subsequently targets a subnuclear location to suppress Runx2-mediated osteocalcin promoter activation in rat osteosarcoma cells [54]. The gene discussed is RUNX2; the disease is osteosarcoma.