Interestingly, a new technology based on the in vivo detection of a-Casp3 expression in the retina, known as DARC (Detection of Apoptosing Retinal Cells), is currently being translated from preclinical models to patients as a predictive tool for glaucoma progression, as a-Casp3 expression is an event that occurs prior to fibre layer thinning. This evidence concerns the gene ACKR1 and glaucoma.