TNF and cancer: Additionally, 24 pathways related to all core targets were found in KEGG pathway analysis (P-adjust < 0.05), which included the nuclear factor kappa-B (NF-κB) signaling pathway, TNF signaling pathway, staphylococcus aureus infection, human cytomegalovirus infection, microRNAs in cancer, serotonergic synapse, natural killer cell mediated cytotoxicity, Influenza A, and kaposi sarcoma-associated herpesvirus infection (Fig. 3F).