VEGFA and neoplasm: Previous studies have found that the ‘normalization’ of the tumor vasculature by anti-VEGF agents plays a key role in combinatorial benefits because VEGF inhibition could result in the pruning of endothelial cells not covered by pericytes and a reduction in the tortuosity and hyperpermeability of tumor vessels which are expected to reduce tumor interstitial pressure and lead to enhanced uptake of cytotoxic agents and antibodies by the tumor [76].