BBS10 and Bardet-Biedl syndrome: Taken together, this altered expression profile in JS-iPSC cultures appears consistent with an inadequate activation of genes controlling neuronal/cerebellar differentiation, a situation not dissimilar to that seen in iPSCs from patients with Bardet-Biedl syndrome mutated in BBS10, which responded to neural crest differentiation with a lower neural crest genes expression and incomplete differentiation (Barrell et al. 2019).