CASP3 and neoplasm: Consequently, we observed enhanced tumor growth delay and significantly increased apoptosis upon STING activation followed by ICB compared with STING activation alone (for cleaved caspase 3: ADU-S100 vs. ADU-S100 plus anti–PD-1, P < 0.0001; for cleaved PARP: ADU-S100 vs. ADU-S100 plus anti–PD-1, P = 0.0007).