Coculture of DARIC33 T cells with AML cells of various rs12459419 SNP genotypes (21, 22) including OCI-AML3 (T/T), U-937 (C/C), HL-60 (C/C), MV4-11 (C/T), and MOLM14 (C/C) stimulated similar rapamycin-dependent release of IFN-γ and IL-2 (Figure 3E), despite different CD33M expression density (assessed using IgV2-targeted p67.6 antibody; Supplemental Table 1). The gene discussed is RUNX2; the disease is acute myeloid leukemia.