S100B and injury: In a before-and-after study conducted in 1062 children at intermediate risk of clinically important traumatic brain injury,34 the implementation of a modified Paediatric Emergency Care Applied Research Network rule including S100B assay significantly reduced the proportion of CCT scans and in-hospital observations for children with minor HT by 34% (95% CI, 10.3%-54.6%) and 45.2% (95% CI, 39.9%-51.3%), respectively.